long stress induced non-coding transcripts 5 rs2962586 polymorphism in iranian patients with bladder cancer

background: bladder cancer (bc) is the most common genitourinary cancer in iranians with an unclear etiopathogenesis. long stress induced non-coding transcript 5 is a member of the 12-member family of long non-coding rnas, which is abundantly expressed in higher proliferative cells, as well as the cell vulnerable to cellular stress in response to chemical carcinogens. as variations in long non-coding rnas have been suggested to involve in cancer pathogenesis, this case-control study was performed to determine whether lsinct5 rs2962586 polymorphism is associated with bladder cancer. materials and methods: a group of 150 patients with bc were compared with 143 subjects as a control group. genotyping of the rs2962586 polymorphism in exon region of the transcript was done using tetra- primer amplification refractory mutation system-polymerase chain reaction (t-arms pcr) method. results: no allelic or genotypic association of the studied polymorphism was observed in this study. however, repeating the analysis in a separate group’s base on smoking resulted in a significant increased risk of bc among smokers. conclusion: considering the result of our analyses, it seems that lsinct5 could not affect individual susceptibility to bc among iranian patients, however, it can be considered as a disease predictor among smokers.